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*While the type of opioid and amount should be individualized to each patient factoring the extent of surgery, patient goals, and clinician recommendation, the pills listed are presented as oxycodone 5mg pill equivalent.

**Oxycodone 5 mg tablet by mouth every 6 to 8 hours for the first 2 days as needed for pain, and then if severe pain persists then may continue taking one tablet every 12 hours for an additional few days.

Download a PDF of these guidelines here

To download our full Post-Surgical Opioid Prescribing Guidelines with clinician guidance on pre-op, intra-op, and post-op prescribing recommendations please click here

Please Note

All medications require a thorough evaluation for contraindications. Doses given are recommendations. Adjustments may be required for individual patients. In case of patient allergy to Oxycodone, replace 5mg Oxycodone with 2 mg Hydromorphone (Dilaudid).

Some examples of relative contraindications:

  1. Gabapentin: renal dosing in chronic kidney disease

  2. Acetaminophen : contraindicated with liver disease or elevated LFTs

  3. NSAIDS: contraindicated with bleeding risks, GI ulcers and chronic kidney disease

  4. Tramadol: contraindicated with patient on SSRI and those with history of seizure

COX-2 Selective Inhibitor, Celecoxib

Give to postop patients who are unable to receive ketorolac because they have a history of GI ulcers or bleeding. Also give preop to orthopedic patients who do not have any contraindications.

Dosing: Give 200 mg 1-2 hours before surgery and every 12 hours for 5 days. Decrease daily dose by 50% in patients with hepatic impairment (Child-Pugh Class B).

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Marty Makary, MD, MPH, Surgeon Lead

Marie Hanna, MD, MBBCh, Pain Management Lead

Christian Jones, MD, MS, Gen. Surgery

Lisa Kodadek, MD, Gen. Surgery

James Taylor, MD, MPH, Gen. Surgery

Heidi Overton, MD, Gen. Surgery

Zachary Enumah, MD, Gen. Surgery

Christi Walsh, CRNP, Gen. Surgery

Mehran Habibi, MD, MBA, Breast Surgery

Kayode Williams, MD, MBA, Anesthesiology

Jon Russell, MD, ENT

Mark Bicket, MD, Anesthesiology

Joanna Etra, MD, Gen. Surgery

Stephen Broderick, MD, Thoracic Surgery

Tiffany Zavadsky, RN, Patient Representative

Brian Matlaga, MD, MPH, Urology

Clark Johnson, MD, MPH, Ob/Gyn 

Jeanne Sheffield, MD, Ob/Gyn

Ronen Shechter, MD, Anesthesiology

Hien Nguyen, MD, Hernia Surgery

Greg Osgood, MD, Orthopaedic Surgery

Richard Burkhart, MD, Gen. Surgery

Alex Blair, MD, Gen. Surgery

Wes Ludwig, MD, Urology

Suzanne Nesbit, PharmD

Matthew Pickering, PharmD

Susan Hutfless, PhD, MS, Research Team

Peiqi Wang, MD, MPH, Research Team

William Bruhn, Research Team

Suzette Morgan, Patient Representative


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